A specific rash is associated with ABC hypersensitivity and may also present with nausea, vomiting, diarrhea, fever, shortness of breath, or hypotension.³⁴ The initial presentation of the ABC rash may not be as serious as the rash provoked by NVP; however, if an ABC rash has occurred, anaphylaxis is possible upon rechallenge with ABC.³⁵ Thus, once ABC is stopped due to rash, it should not be used again. ³⁶ Any patient receiving ABC who reports a rash should be evaluated immediately. If hypersensitivity is diagnosed, stop ART and provide supportive care, including aggressive hydration and blood pressure support if needed. Once the patient is hemodynamically stable, ART may be resumed; as noted above, the patient should never receive ABC again. Protocol 3.7 gives management information for ABC hypersensitivity.