Problems of the skin and mucous membranes may affect up to 90 percent of HIV-infected people and can occur at all stages of the disease. Mucocutaneous reactions may be associated with the HIV virus itself, immunologic effects of the disease, OIs, or the medications used to treat HIV. All patients who present with cutaneous mucuous membrane problems should be questioned as to the duration of the problem; the presence of itching, pain, bleeding, discharge, lumps, or sores; and recent sexual history. The patient should also be questioned as to whether her partner(s) or family members have similar symptoms. Appendix F presents an overview of dermatological conditions common among HIV-infected patients.